Alcohol Change UK said these deaths were an “avoidable tragedy”, as the charity called for further action on the marketing, labelling, and pricing of alcohol.
Figures from the Office of Health Improvement and Disparities show there were 63 deaths in Wiltshire wholly caused by alcohol consumption in 2023.
This was up from 58 deaths the year before and the highest number since comparable records began in 2006.
Across the South West, there were 802 deaths in 2023.
The national number of deaths reached 8,274 last year – a 5% jump from the year before and the highest since records began.
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The pandemic caused a significant rise in these deaths, with last year’s figure up 42% on 2019.
Dr Richard Piper, Alcohol Change UK chief executive, said: “Every time someone dies from alcohol, it is an avoidable tragedy.”
He added: “And there are millions of us whose lives are negatively affected by alcohol, be that through hangovers, over-spending, under-performing at work, or just not being fully present for our friends or family.
“None of this is inevitable, and we are seeing a growing acceptance, particularly among younger generations, that alcohol is an optional, not essential, part of our lives. These cultural shifts are even more possible when systemic changes are made.”
The rate of alcohol mortality across the country also reached its highest level at 15 deaths per 100,000 people.
Wiltshire had a mortality rate of 11.7 deaths per 100,000 people.