The Warrington Guardian revealed M&S Outlet will open later this year on Riverside Retail Park.
The former Golden Square store shut in the summer of 2017.
But the brand has a long history in Warrington.
Marks moved into Golden Square Shopping Centre when the first phase of the development opened in 1977.
But the shop had been serving generations of residents long before the town centre mall was built.
Janice Hayes, a respected Warrington historian, said Marks and Spencer first opened as a stall in the old Warrington Market.
It was successful enough to move into a small shop, which may have been in Bridge Street, before moving into the store many people will remember on Sankey Street.
Janice said: “Marks and Spencer arrived in Sankey Street in the 1930s in anticipation of the imminent plans to widen the street and redevelop the Market Place.
“It was designed with a temporary single storey frontage which soon became a permanent feature.
“Eventually pedestrianisation replaced road widening schemes and in 1977 a new Marks and Spencer’s store opened in the first phase of Golden Square.
“In 1978 the original store on Sankey Street and its neighbours were demolished.”
Marks and Spencer was founded in 1884 by a Polish refugee, Michael Marks, who opened the chain’s first market stall in Leeds.
The brand operates a large store at Gemini as well as a popular food hall at the Forge Shopping Centre in Stockton Heath.